On March 31, 2025, a collaborative study led by Professor Jesper Olsen’s team at the University of Copenhagen and Dr. Zilu Ye’s team at the Chinese Academy of Medical Sciences/Suzhou Institute of Systems Medicine was published online in Cell under the title "Global Analysis of Protein Turnover Dynamics in Single Cells." The research developed an advanced single-cell proteomics technology called SC-pSILAC (Single-Cell Pulsed Stable Isotope Labeling by Amino Acids in Cell Culture), enabling for the first time the simultaneous precise measurement of protein abundance and turnover rates at the single-cell level. This breakthrough provides a novel dimension and perspective for studying cellular heterogeneity.

The localization and interactions of proteins are fundamental to their biological functions, making it critical to understand their roles within cells and tissues. Spatial proteomics technology enables high-resolution, in-depth protein analysis while preserving the spatial integrity of cells and tissues, thereby advancing our understanding of intracellular signaling, intercellular communication, and interactions with the extracellular matrix. Recognized as the Nature Methods 2024 Method of the Year, spatial proteomics has demonstrated its revolutionary potential in unraveling biological complexity and advancing precision medicine and cancer research.

In a groundbreaking study published in Cell, an international research team led by Prof. Yansheng Liu from Yale School of Medicine, in collaboration with Prof. Junmin Peng from St. Jude Children’s Research Hospital and Prof. Eugenio F. Fornasier from the University Medical Center Göttingen, has systematically mapped the protein turnover dynamics across multiple mouse tissues and brain regions. 

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